Motif ID: FOX{F1,F2,J1}.p2

Z-value: 1.315


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXJ1hg19_v1_chr17_-_74137370_74137379-0.373.5e-02Click!
FOXF2hg19_v1_chr6_+_1390068_1390182-0.222.3e-01Click!
FOXF1hg19_v1_chr16_+_86544104_865442080.048.3e-01Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_161193190 7.709 APOA2
apolipoprotein A-II
chr1_+_207277577 7.200 NM_000715
 C4BPA
complement component 4 binding protein, alpha
chr1_-_161193375 6.990 NM_001643
 APOA2
apolipoprotein A-II
chr4_+_155484131 6.821 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr22_+_21128378 5.489 NM_000185
 SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_57431620 4.762 NM_000066
 C8B
complement component 8, beta polypeptide
chr11_+_124789145 4.762 NM_001037558
 HEPN1
hepatocellular carcinoma, down-regulated 1
chr12_-_96390002 4.167 NM_002108
 HAL
histidine ammonia-lyase
chr4_+_74269971 4.166 NM_000477
 ALB
albumin
chr1_+_40862471 3.800 NM_001198980
 SMAP2
small ArfGAP2
chr8_+_120079423 3.754 NM_006438
 COLEC10
collectin sub-family member 10 (C-type lectin)
chr4_-_72671236 3.314 NM_001204306
 GC
group-specific component (vitamin D binding protein)
chr17_-_7082559 3.295 ASGR1
asialoglycoprotein receptor 1
chr17_-_26697358 3.259 NM_000638
 VTN
vitronectin
chr17_-_7082654 3.214 NM_001197216
NM_001671
 ASGR1

asialoglycoprotein receptor 1

chr2_-_21230572 3.186 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_26697224 3.155 VTN
vitronectin
chr17_-_26697310 3.027 VTN
vitronectin
chr2_-_21231406 2.982 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_26697293 2.922 VTN
vitronectin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
Enrichment   P-value GO Accession GO Term
165.57 2.55e-02 GO:0010949 negative regulation of intestinal phytosterol absorption
165.57 2.55e-02 GO:0045796 negative regulation of intestinal cholesterol absorption
82.79 2.98e-03 GO:0030300 regulation of intestinal cholesterol absorption
62.09 8.26e-03 GO:0032372 negative regulation of sterol transport
62.09 8.26e-03 GO:0032375 negative regulation of cholesterol transport
49.68 1.75e-02 GO:0034374 low-density lipoprotein particle remodeling
41.40 1.52e-03 GO:0015721 bile acid and bile salt transport
41.40 3.19e-02 GO:0043252 sodium-independent organic anion transport
26.86 5.84e-05 GO:0008206 bile acid metabolic process
18.93 4.00e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
16.29 1.24e-03 GO:0010951 negative regulation of endopeptidase activity
13.58 2.32e-02 GO:0072376 protein activation cascade
13.25 4.20e-03 GO:0002576 platelet degranulation
12.55 3.41e-02 GO:0055088 lipid homeostasis
10.81 1.37e-02 GO:0010466 negative regulation of peptidase activity
9.21 3.40e-02 GO:0019933 cAMP-mediated signaling
9.14 8.20e-03 GO:0051346 negative regulation of hydrolase activity
8.17 1.70e-02 GO:0002252 immune effector process
8.00 1.94e-02 GO:0019935 cyclic-nucleotide-mediated signaling
7.86 1.06e-04 GO:0051241 negative regulation of multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
70.96 8.75e-04 GO:0005577 fibrinogen complex
22.30 2.99e-06 GO:0031983 vesicle lumen
21.14 4.33e-05 GO:0031093 platelet alpha granule lumen
20.70 4.93e-05 GO:0034774 secretory granule lumen
19.88 6.32e-05 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
17.44 1.40e-04 GO:0031091 platelet alpha granule
5.80 2.47e-02 GO:0030141 stored secretory granule
4.45 1.87e-06 GO:0005615 extracellular space
3.94 1.29e-06 GO:0044421 extracellular region part
3.22 3.55e-09 GO:0005576 extracellular region
3.04 2.32e-02 GO:0005624 membrane fraction
2.94 3.22e-02 GO:0005626 insoluble fraction
2.72 1.72e-02 GO:0000267 cell fraction
2.12 1.65e-02 GO:0044459 plasma membrane part
1.94 1.51e-04 GO:0005886 plasma membrane
1.92 2.30e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
110.38 1.71e-02 GO:0004873 asialoglycoprotein receptor activity
60.21 6.30e-05 GO:0017127 cholesterol transporter activity
50.95 1.35e-04 GO:0015248 sterol transporter activity
31.05 1.78e-02 GO:0015125 bile acid transmembrane transporter activity
31.05 1.78e-02 GO:0070325 lipoprotein particle receptor binding
29.23 2.16e-02 GO:0043499 eukaryotic cell surface binding
15.06 2.22e-02 GO:0043498 cell surface binding
13.36 5.62e-03 GO:0005319 lipid transporter activity
11.43 2.22e-03 GO:0004867 serine-type endopeptidase inhibitor activity
10.45 7.54e-04 GO:0008201 heparin binding
9.02 4.65e-04 GO:0005539 glycosaminoglycan binding
8.34 8.34e-04 GO:0001871 pattern binding
8.34 8.34e-04 GO:0030247 polysaccharide binding
6.81 4.01e-02 GO:0004866 endopeptidase inhibitor activity
6.55 4.98e-02 GO:0061135 endopeptidase regulator activity
5.45 3.14e-04 GO:0030246 carbohydrate binding